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E952SweetenerModerate concern
Cyclamate
In plain words
The short version
A high-intensity artificial sweetener — banned in the US since 1970 but permitted in the EU and much of the world.
Why we flag it amber
It's permitted and generally considered safe, but there are a few reasons to be mindful — like sensitivities in some people, debated studies, or intake limits. The Safety section below explains the specifics.
Safety profile
ADI of 0–7 mg/kg body weight. The original 1969 rat-tumor finding was not replicated in subsequent studies; current EFSA and JECFA positions support safety at the ADI. Roughly 30% of human populations metabolize cyclamate to cyclohexylamine via gut bacteria — relevance to chronic toxicity remains debated.
The detail
Educational information only. Not medical or dietary advice.