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E216PreservativeModerate concern

Propylparaben

In plain words

The short version

Propyl 4-hydroxybenzoate — de-listed in EU food in 2006 over endocrine concerns; still in use elsewhere.

Why we flag it amber

It's permitted and generally considered safe, but there are a few reasons to be mindful — like sensitivities in some people, debated studies, or intake limits. The Safety section below explains the specifics.

01Origin

Where it comes from

Manufactured by esterifying p-hydroxybenzoic acid with 1-propanol. A natural component of trace amounts in many plants (the family is biosynthetically widespread).

02Usage

How it's used

Use is restricted in the EU (food authorization revoked in 2006) and several other jurisdictions. Still present in non-EU bakery and confectionery markets; cosmetic and pharmaceutical use continues under separate regulatory regimes. Effective broad-spectrum antifungal across pH 3–8.

03Safety

Safety profile

ADI of 0–2 mg/kg body weight (where still permitted, EFSA's pre-revocation level). Weakly estrogen-receptor active in vitro at high concentrations — the human-dietary relevance triggered the EU revocation as a precaution.

04Properties

Physical & chemical properties

White crystalline powder. Practically insoluble in water; soluble in ethanol and oils. Heat-stable.

05Regulation

Regulation worldwide

De-listed for EU food use since 2006. Permitted in the US, Canada, Asia-Pacific, and Latin America with maximum-use limits.

Educational information only. Not medical or dietary advice.