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E433EmulsifierElevated concern
Polysorbate 80
In plain words
The short version
A common surfactant in ice cream, sauces, and pharmaceuticals — a central focus of gut microbiome research.
Why we flag it
It's allowed, but comes with clearer cautions — such as reactions in sensitive people, stricter limits, or contested safety. The Safety section below explains why.
Safety profile
ADI of 25 mg/kg body weight (combined polysorbates). A widely cited 2015 study (Chassaing & Gewirtz, Nature) showed that polysorbate 80 at low doses altered gut microbiota and induced low-grade intestinal inflammation in mice. Subsequent human studies are limited but the topic is among the most active areas in emulsifier safety research.
The detail
Educational information only. Not medical or dietary advice.