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E338AcidulantModerate concern

Phosphoric Acid

In plain words

The short version

The signature acidulant of cola drinks — provides the characteristic sharp 'bite'.

Why we flag it amber

It's permitted and generally considered safe, but there are a few reasons to be mindful — like sensitivities in some people, debated studies, or intake limits. The Safety section below explains the specifics.

Safety

Safety profile

JECFA set a maximum tolerable daily intake (not an ADI) of 70 mg/kg body weight for phosphorus from all sources in 1982. In 2019 EFSA set a group ADI of 40 mg/kg body weight per day for phosphates, expressed as phosphorus, and estimated that phosphorus intake from the whole diet in infants, toddlers and other children exceeded it at the mean level. Long-term high intake (mainly from cola consumption) has been associated with reduced bone mineral density in observational studies — the calcium-phosphorus balance is the proposed mechanism. Strong erosive effect on tooth enamel.

The detail

Sources

  1. EFSA — Re-evaluation of phosphoric acid–phosphates – di-, tri- and polyphosphates (E 338–341, E 343, E 450–452) as food additives and the safety of proposed extension of use (EFSA Journal 2019;17(6):5674) — EFSA Panel on Food Additives and Flavourings (FAF), EFSA Journal (via PubMed Central), 2019. EFSA group ADI 40 mg/kg bw per day as phosphorus; intakes above ADI in children
  2. WHO JECFA database — Phosphoric acid (INS 338), evaluation 1982 (26th meeting) — WHO / Joint FAO/WHO Expert Committee on Food Additives, 1982. JECFA value of 70 mg/kg bw is a group MTDI for phosphorus from all sources, not an ADI
  3. 21 CFR 182.1073 — Phosphoric acid (GRAS), eCFR current as of 2026-10-13 — U.S. eCFR (Office of the Federal Register / GPO), 2026. US status: GRAS under good manufacturing practice

Checked against these sources on .

Educational information only. Not medical, dietary or veterinary advice. Spotted an error? Tell us.